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142 In addition, ERAD directly restrains hepatic lipogenesis by targeting ATP-citrate lyase (Acly), a key enzyme that channels citrate toward fatty acid synthesis

Although ROS are integral to physiological signaling, their uncontrolled accumulation shifts the redox equilibrium toward oxidative damage, emphasizing the delicate balance required for cellular homeostasis

Classical gynecomastia from the growth of actual breast glands can also occur as a result of obesity

When sheep are either supplemented with or deprived of selenium, their brains maintained similar levels of SELENOW, suggesting the critical need for SELENOW homeostasis in the brain (Yeh et al., 1997)