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In transverse aortic constriction (TAC) model rats, TSA markedly reduced malondialdehyde (MDA) levels in myocardial tissue and decreased pro-inflammatory cytokine levels (TNF- and IL-6), while increasing superoxide dismutase (SOD) activity, ultimately attenuating pressure overload-induced cardiac remodeling (45)

This paradigm shift in peptide engineering combines data-driven insights with traditional rational design principles, substantially expanding the landscape of feasible peptide therapeutics

Furthermore, electron spin resonance (ESR) spectra proved that CeNPs efficiently scavenged the OH radicals generated by the Fenton reaction (Fig

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