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There are also small differences in the concentrations of small cations and anions between interstitial fluid and plasma, explained by the Gibbs-Donnan effect of the negatively charged plasma proteins (see Chapter 1 )

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These posttranslational modifications may also be a prerequisite for interactions of BDNF with chaperones or sorting receptors that guide the secretory protein BDNF predominantly to vesicles of the regulated secretory pathway (reviewed in Lemann and Brigadski 2009)