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Rodent blood is more resistant to methaemoglobin formation than human blood (Kruszyna et al., 1982)

check their B12 status, and request it to be checked if it is not available, ensure the levels are more than 300 pmol/L and not above the recommended upper limit, recommend reducing frequency of the intervention if the levels are at the high end of normal range or above range

Individuals taking high-dose B12 supplementswhether oral, sublingual, or intramuscular injectionsmay develop elevated serum levels, particularly if supplementation exceeds physiological requirements

Its proposed mechanisms involve multiple cytoprotective pathways including upregulation of VEGF and growth factors promoting angiogenesis, modulation of the nitric oxide system, activation of the FAK-paxillin pathway for cell migration and tissue repair, interaction with the gut-brain axis affecting dopaminergic and serotonergic systems, and gastroprotective effects against NSAID and alcohol-induced mucosal damage