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2.7 Pathogenesis of Alzheimers disease AD is driven by a complex interplay of genetic, molecular, and environmental factors, resulting in progressive neurodegeneration and cognitive impairment (Yuksel and Tacal, 2019)

Abbreviations: A: antagonist, U: uptake, I: inhibitor, MAO: monoamine oxidase, OC: oral contraceptives, 5HT: 5-hydroxytryptamine

Access this article Similar content being viewed by others Abbreviations AM: Allyl meracaptan CaMK II: Calcium/calmodulin-dependent kinase II CDK: Cyclin dependent kinase Cyl: Cylindrocladium scoparium DADS: Diallyl disulfide DNMT: DNA methyltransferases ESCC: Esophageal squamous cell carcinoma GLUT-4: Glucose transporter type 4 HAT: Histone acetylases HC: Helminthosporium carbonum HDAC: Histone deacetylase HDACi: Histone deacetylase inhibitor HIF-1 : Hypoxia inducible factor 1 HSF-1: Heat shock factor-1 LAM-2: Lysosomal-associated membrane protein 2 NAD: Nicotinamide adenine dinucleotide NES: Nuclear export signal NF-B: Nuclear factor kappa B NLS: Nuclear localization signal PDGF: Platelet derived growth factor PEPCK: Phosphoenol pyruvate carboxykinase Psam A: Psammaplin A ROS: Reactive oxygen species SAHA: Suberanilohydroxamic acid SB: Sodium butyrate SFN: Sulforphane SIRT: Sirtuin SP: Sodium propionate TRAIL: Tumor necrosis factor-related apoptosis-inducing ligand TSA: Trichostatin A VEGF: Vascular endothelial growth factor ZBG: Zinc binding group References Ahn MY, Jung JH, Na YJ, Kim HS (2008) A natural histone deacetylase inhibitor, Psammaplin A, induces cell cycle arrest and apoptosis in human endometrial cancer cells

Specific hereditary backgrounds are implicated, such as FOXP3 pathogenic variants in immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, and autoimmune regulator (AIRE) mutations in APS type 1 (Klubo-Gwiezdzinska And Wartofsky 2022)