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These signs and symptoms may vary depending on which hormones or glands are affected, but some common ones include: Weight gain or loss Fatigue or muscle weakness Mood swings or depression Anxiety or irritability Increased or decreased appetite Increased or decreased thirst Frequent urination Increased or decreased heart rate Increased or decreased sensitivity to cold or heat Constipation or diarrhea Blurred vision Infertility or low sex drive Hair loss or thinning Dry skin or acne Puffy face or rounded face Purple or pink stretch marks However, these signs and symptoms are not specific to hormonal imbalances and may also be caused by other factors or conditions

K., et al

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The peptide that does penetrate stays mostly local, limiting systemic effects