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Results of Co-IP experiments revealed that Dlgap5 overexpression enhanced the interaction of NLRP3 and ASC in PYD domain and the binding of ASC and pro-CASPASE-1 in CARD domain, demonstrating the essential role of DLGAP5 in driving inflammasome formation and assembly through enhanced structural domain interactions (Figure 5M)

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Research on tumor metabolism can be traced back to the 1920s when German biochemist Otto Warburg first described that tumor cells tend to produce energy through glycolysis, even in the presence of sufficient oxygen, a phenomenon later known as the Warburg effect (Koppenol et al., 2011

NAC is provided as N-Acetyl-L-Cysteine and paired with NAD as Nicotinamide Adenine Dinucleotide