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Description

The nuclear factor E2-related factor 2 (Nrf2)-related anti-oxidative stress is strongly associated with ferroptosis suppression

Furthermore, high extracellular Glu will inhibit system xc , leading to ferroptosis

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The use of Drosophila bring to the study of oxidative liver injury many advantages, including ease of genetic manipulation, availability of genetic mutants and constructs, ease of germ-free generation, relatively short lifespan, amenability to high-throughput screening, and overall cost relative to murine models 40