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Regulatory T cell (Treg) development is also stimulated during hookworm infection ( Figure 1 Increasing Burden of Autoimmune Disease Autoimmunity is the failure of the immune system to distinguish pathogens from self-antigens resulting in damage to healthy tissue ( Dirty Old Friends The hygiene hypothesis, formulated in 1989, proposed that lower intensities of infections during early childhood could explain the emergence of asthma and hay fever later in life ( Concordantly, the old friends hypothesis suggests that various organisms, including helminths and microbiotas, have long coevolved with their mammalian hosts and act as inducers of immunoregulatory circuits ( Animal Models of Helminth Therapy Over the last decades, there have been numerous animal models used to study hookworm therapy for autoimmune disease (IBD, MS, RA, and T1D)

For monochromatic light sources, photolysis is higher in the short wave length region

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[DOI] [PubMed] [Google Scholar] 82.Coombes JS, Powers SK, Hamilton KL, Demirel HA, Shanely RA, Zergeroglu MA, Sen CK, Packer L, Ji LL