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AKT activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart

The 50, 12.5 and 10 M data (test concentrations) were withheld to be used for blind validation

Their highly electrophilic N=C=S core reacts readily with many biological nucleophiles 14 , through conjugation to exposed nucleophilic residues and cleavage of disulfide bonds, resulting in the disruption of protein tertiary structures and active sites 15,16