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If supplementation is required, the doses are much higher than the following requirements

Transgenic overexpression of insulin-like growth factor I prevents streptozotocin-induced cardiac contractile dysfunction and ??-adrenergic response in ventricular myocytes

1,8-diMQ and 5-amino-1MQ showed little inhibition of COMT at maximal tested concentrations of 200 M (20% inhibition) and 600 M (10% inhibition), respectively, although no clear trend of concentration-dependent inhibition was observed

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