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& Tsan, M

55 Although some of the TNFR ligands are also expressed on activated T cells, the T cellT cell interaction, especially under in vitro conditions, only trigger weak activation of noncanonical NF-B, which can be greatly enhanced by cross-linking the TNFR OX40

The cause of melasma is not fully understood, but scientists suspect that hormones, UV exposure, chronic inflammation, and genetics may all play a role