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Actigraphic evidence and polysomnography studies have detected higher density of REM sleep, greater variability in sleep patterns, longer sleep latency and duration, lower sleep efficiency, greater number of arousals, fragmented sleep, and reduced daily activity, both in actively ill and remitted bipolar patients, relative to healthy controls (181184)

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These ingredients can potentially destabilize the peptide complex or increase the risk of irritation when used simultaneously

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