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As real-world examples, the collaboration between Insitro and Bristol-Myers Squibb (BMS), showcased how ML-driven drug discovery promises to disentangle the complexity of disease (e.g., amyotrophic lateral sclerosis, ALS), and identify novel genetic targets, to potentially discover disease-modifying medicine [22]

reported that the N-TXNIP(C36S/C49S/C120S) structure contains a Cys63-Cys63 intermolecular disulphide bond 39 that causes a conformational change of the 5 and 6 strands in crystallographically independent molecules (Fig

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