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Endocrinology 141 : 26082613 Liu JL et al

Neuropathy, often called peripheral neuropathy, isnt a single condition but rather a group of conditions arising from nerve damage in the peripheral nervous system

Nevertheless, use of metformin may decrease vitamin B 12 status: a meta-analysis of four short-term intervention trials (up to 4 months duration) in patients with type 2 diabetes found that metformin use decreased serum cobalamin concentrations by 57 pmol/L, which could have clinical implications if such patients have suboptimal vitamin B 12 status (146)

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