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The cerebellum is one of the most affected tissues in FRDA pathology 7, 16, 17, 18 and cerebellar granule neurons have previously been shown to be lost in an inducible Fxn knockout FRDA mouse model

Based on current published evidence, RBCs can be an interesting example as a model to examine the relationship between biochemical redox reactions and the maintenance of their physiological properties

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The findings of this study suggest that toxic A peptides facilitate the oxidation of ascorbate through interactions with copper ions, leading to the production of hydroxyl radicals via the Fenton reaction (Valko et al., 2005[430]), the source of oxidative damage and neurotoxicity in the Alzheimer's disease brain