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SIRT6 on EndMT in mice and human HUVECs revealed that co-treatment with TNF- and IL-1 promotes EndMT and reduces SIRT6 expression (Vijakumaran et al., 2023)

The following figure illustrates the drop in ferritin (and thus iron stores) after blood donation and quantifies the iron loss per unit: At Nervana Medical, we often see this pattern in men on testosterone therapy who undergo repeated phlebotomy and need iron treatment to battle their fatigue despite having optimized their testosterone

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These effects are especially relevant for individuals with HIV-associated lipodystrophy, who may face both physical and psychological challenges