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Additionally, most studies have been conducted over short durations, which might not allow time for adverse effects to manifest

HK2 cells and HUVECs were stimulated by LPS, and CCK-8 assay showed that cell viability in the LPS treatment group was significantly lower than that in the control group, while estradiol and (+)-JQ1 compound treatment significantly increased the viability of HK-2 cells and HUVECs (Fig