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elegans the intestine is a large organ that carries out multiple functions executed by distinct organs in higher eukaryotes, including digestion of food, absorption of processed nutrients, synthesis and storage of macromolecules, initiation of an innate immune response to pathogens, and nurturing of germ cells by producing yolk (IntFIG 1) (Kimble and Sharrock, 1983

Although these findings of dysbiosis in ME/CFS are evident [12, 21,22,23,24,25,26,27,28,29,30,31], their exact role in the disease mechanism remains unclear [10]

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This paper was the first to unambiguously show that DAG and phorbol esters bind to the same site on PKC, providing reliable evidence that the phorbol esters function by mimicking the action of DAG