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28-day, ICU and in-hospital mortality The odds of 28-day mortality and in-hospital mortality was reduced in PCT guidance compared to SOC, the former being statistically significant (OR 0.84, 95% CI: 0.74, 0.95, p = 0.008 (Additional file 1: Figure S2) and OR 0.85, 95% CI: 0.66, 1.10 (Additional file 1: Figure S3), respectively)

MOTSc is studied in preclinical models to better understand metabolic signaling (how cells coordinate energy use), cellular energy regulation (how cells respond when energy demand changes), and mitochondrial homeostasis (how mitochondria maintain stable function)

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2.8 Permeability to lactulose The protocol for measuring monolayer permeability to lactulose was adapted from (37)