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Flavonoids, although often less acutely toxic, modulate herbivore behavior and physiology by inhibiting detoxification enzymes, acting as feeding deterrents, or mimicking hormone signals, and also contribute to resistance against pathogens as phytoalexins synthesized de novo upon infection

Intake of watermelon or its byproducts alters glucose metabolism, the microbiome, and hepatic proinflammatory metabolites in high-fat-fed male C57BL/6 J mice