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While few studies have examined the metal binding and/or disulfide status of wild-type SOD1 in ALS, the lack of such post-translational processes is expected to result in the decrease of its enzymatic activity

Any concomitant treatment or therapeutic interventions that participating children might receive will be recorded during assessment sessions before randomisation and following the primary endpoint, specifying the kind and amount or frequency of intervention

No high-quality clinical trial has demonstrated that B12 injections produce meaningful weight loss outcomes independent of dietary and exercise changes

Mol Neurodegener