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However, no single OS marker is representative in determining how healthy an individual is, or in predicting his life expectancy, while a set of clinical biomarkers, including lipid peroxidation and protein oxidation products, and antioxidative acting enzymes, could be used to delineate the oxidation status of a person [328]

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In turn, LATS1/2 phosphorylation triggers YAP activation, causing YAP capture by 4-3-3 proteins in the cytosol or degradation by SCF-TRCP E3 ubiquitin ligase-mediated ubiquitin-proteasome signaling

Ethics declarations Ethical approval The project was approved by the Italian Ministry of Health and the internal Committee of the University of LAquila (authorization n