You want no resistance at all when you poke it
This imbalance between enhanced fission and suppressed fusion leads to structural fragmentation, metabolic uncoupling and deterioration of respiratory chain function, all of which contribute to bioenergetic failure
Whole grains, legumes, fish, seafood, and meat are just a few examples

These molecular alterations trigger a number of interrelated pathomechanisms, namely: i) free-thiol oxidation of proteins;6,7ii) disassembly of cytoskeleton,8,9 with plasma membrane blebbing as a major emergent;10iii) formation of mitochondrial permeability transition pores, leading to the release of mitocondrial promoters of apoptosis (cytochrome c, Smac/DIABLO) and uncoupling of the electron transport chain from ATP production, with eventual necrosis associated with ATP depletion;11iv) increased plasma-membrane peroxidation, leading to membrane permeabilization and leakage of cytosolic components;12v) oxidative breaking of DNA strands, leading to genotoxicity and carcinogenesis;13,14vi) elevation of intracellular Ca2+ levels, which facilitates mitochondrial permeability transition and activation of Ca2+-dependent proteases, endonucleases, and lipases.11,15 Due to its multiple energy-dependent functions, liver has a high mitochondrial metabolic rate, and is heavily engaged in detoxification mechanisms that involve redox-enzyme systems
