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Be aware that websites from other countries may contain information that differs from New Zealand recommendations: Methotrexate(external link) RheumInfo Methotrexate(external link) Medsafe Consumer Information Sheet, NZ Methotrexate(external link) Australian Rheumatology Association Methotrexate(external link) Arthritis UK Brochures Low-dose methotrexate for rheumatoid arthritis and psoriatic arthritis(external link) NPS MedicineWise, Australia Low-dose methotrexate for plaque psoriasis action plan(external link) NPS MedicineWise, Australia Low-dose methotrexate for Crohn's disease(external link) NPS MedicineWise, Australia 5 questions to ask about your medications(external link) Health Quality and Safety Commission, NZ English(external link), te reo Mori(external link) References Methotrexate(external link) New Zealand Formulary Spotlight on weekly methotrexate(external link) Medsafe Prescriber Update, NZ, March 2025 Brochures Methotrexate advice BPAC, NZ, 2026 Taking low-dose methotrexate NPS MedicineWise, 2020 Credits: Healthify editorial team

The reaction produces a yellow color but the color is reduced by the presence of a TrxR inhibitor (Tharmalingam et al., 2019)

Mice models and treatments Wild-type (WT) six-week-old C57BL/6 J male mice were purchased from Beijing Vital River Laboratory Animal Technology Co., LTD (Beijing, China)

The human body absorbs less than 10% of vitamins taken orally