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for conducting the next-generation sequencing and assisting with the data acquisition, ELSS, Inc for proofreading and editing the English language of this manuscript, Bloomington Drosophila Stock Centre for providing the Drosophila stocks used in this study, and Japan Collection of Microorganisms RIKEN BioResource Research Centre for providing the bacterial strains used in this research

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Animal studies show that gadolinium can cause low glutathione levels.[ref] Mercury is another heavy metal that utilizes glutathione in the detoxification pathways.[ref] Arsenic exposure causes increased glutathione usage

10 Conclusion and future perspectives The immunometabolic crosstalk between tumor-associated macrophages (TAMs) and ferroptotic cancer cells has emerged as a defining regulator of tumor fate, influencing progression, metastasis, immune evasion, and therapeutic response