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(H-I) Final five residues of subunit B (green sticks) in oxidized (H) (PDB: 22FC) and reduced (I) (PDB: 22EY) states, and distance measurements are indicated by black dashed lines

This ARE element is important for basal promoter activity as well as TNF-mediated induction of rat GCLM (Yang et al., 2005)

ID NO: 134, or an amino acid sequence having at least 75% sequence identity with amino acid sequence 1-139 of any of SEQ ID NOS: 134 and containing the substitution (s) of amino acids 143-448 of SEQ ID NOS: 136-265, or an amino acid sequence having at least 75% sequence identity with amino acid sequences 143-448 of any of SEQ ID NOS: 136- 265 and containing the (s) substitution (s) of amino acid (s) compared to an unmodified FX polypeptide

Department of Economic and Social Affairs Population Division et al., 2013)