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According to recent studies, the acyltransferase p300 acts as a histone Kbhb writer to catalyze the addition of BHB to lysine, and the level of histone Kbhb at the H3K9, H3K18, H3K27, H4K8 sites decreases in response to p300 knockdown and addition of its some of these histone Kbhb sites were more sensitive to p300 knockdown than the corresponding Kac sites ( The reader proteins may specifically recognize certain HPTMs, which in turn regulate downstream gene transcription and influence cellular events

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Our analysis showed that hospitals in the lowest-performing quartile of the Safety of Care measure group tended to receive lower Overall Hospital Quality Star ( Ratings (being more likely to receive 1 or 2 stars and less likely to receive 4 or 5 stars than other hospitals) (Table 141)