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DNMT1 DNA Methyltransferase 1 DNMT3B DNA Methyltransferase 3B PRC2 Polycomb Repressive Complex 2 EZH2 Enhancer of Zeste 2 EED Embryonic Ectoderm Development IL-1b Interleukin-1 Beta IL6 Interleukin 6 EWAS Epigenome-Wide Association Study GPR56 G Protein-Coupled Receptor 56 5-aza-cytidine 5-Azacytidine RG108 A DNA Methyltransferase Inhibitor PD Parkinsons Disease SNCA Synuclein Alpha PARK7 Parkin 7 DJ-1 Parkinsonism Associated Deglycase SLC7A11 Solute Carrier Family 7 Member 11 HOTAIR HOX Transcript Antisense RNA SLC17A6 Solute Carrier Family 17 Member 6 PTPRN2 Protein Tyrosine Phosphatase Receptor Type N2 NR4A2 Nuclear Receptor Subfamily 4 Group A Member 2 PGC1-a Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha FXS Fragile X Syndrome FMR1 Fragile X Mental Retardation 1 CRISPR/Cas9 Clustered Regularly Interspaced Short Palindromic Repeats/Cas9 RRBS Reduced Representation Bisulfite Sequencing AP-1 Activator Protein 1 SOX2 SRY-Box Transcription Factor 2 5-hmC 5-Hydroxymethylcytosine YAC128 Yeast Artificial Chromosome 128 DhMRs Disease-Specific Hydroxymethylation Regions cfDNA Cell-Free DNA DMP Differentially Methylated Probes DMR Differentially Methylated Regions qPCR Quantitative Polymerase Chain Reaction References 1 WisselBDDwivediAKMerolaAChinDJacobCDukerAPet al

It is important to note that all experiments were conducted in triplicate to ensure accuracy and reliability

Dole NS, Mazur CM, Acevedo C, Lopez JP, Monteiro DA, Fowler TW, et al

doi: 10.1093/jxb/erm274 113 LiangB.-W.LiC.BaiT.-H.WangP