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Another significant prospective study evaluated 25 patients with oily skin that received intradermal forehead injections of botulinum toxin and revealed significantly lower sebum production per a sebumeter at one week and one, two, and three months after the injections.[62] Additionally, 91 percent of subjects were satisfied with intradermal botulinum toxin as a treatment for their oily skin.[62] In terms of the mechanism of action, botulinum toxin cleaves proteins involved in vesicle fusion with the plasma membrane of the presynaptic neurons axon terminal

The dura mater, intracranial vessels, trigeminal nerve perivascular fibers, trigeminal ganglion (TG), caudal subnucleus of the trigeminal nucleus caudalis (TNC), hypothalamus, and cerebral cortex are all part of the system (Charles and Brennan, 2010)

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