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TNF- was shown to increase p35 expression, causing Cdk5-mediated TRPV1 phosphorylation and ROS production in nociceptive neurons and increased pain sensation (Sandoval et al., 2018)

PMID 7568330

More recent studies in AD mouse models have indicated that KD improves cognitive function, alleviates neuroinflammation, reduces A plaque deposition, and decreases microglial activation