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Kang et al., 2009), and impairs noradrenergic neurons in the locus coeruleus (Fernagut et al., 2017), solitary nucleus, and catecholaminergic neurons in the pituitary-adrenal system (Edmonds and Edwards, Studies have indicated that PQ dopaminergic neurotoxicity is associated with increased cellular oxidative stress and neuroinflammation, which induces -synuclein aggregation and impairs neurons (Manning-Bog et al., 2002