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Concentrated bone marrow aspirate improves full-thickness cartilage repair compared with microfracture in the equine model

e observed threshold eect at 358.7 pg/mL (OR = 1.04 per 10 pg/mL, 95% CI: 1.001.08, P = 0.03) suggests a pla- teau in B12 benet beyond this level, likely due to satu- ration of methionine synthase activitya mechanism consistent with non-linear enzymatic dose-response rela- tionships, where additional B12 may not enhance meth- ylation capacity [21]

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