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Thus, while the idea that chronic excitotoxicity contributes to multiple neurodegenerative diseases is supported by many layers of scientific evidence, it is not clear that therapeutic interventions that re-establish glutamatergic homeostasis during ongoing neurodegeneration will be effective tools for stopping the disease process

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In a number of studies of patients with MDD, evidence has been found of increased neuroinflammatory markers associated with lower levels of antioxidants (Morris et al