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C9orf72 was also shown to be a Rab guanine exchange factor (GEF) involved in the modulation of Rab activity (Iyer et al., 2018), which regulates NOX2 recruitment to phagosomes in dendritic cells (Jancic et al., 2007)

In addition, the insertion of bulky (compound 76) or strong electron-donating substituents (i.e., NMe 2 , compounds 66 and 69) at the p -position of the N -phenyl ring led to an increase of NS3-NS5 interaction inhibitory activity

This change may be due to a rapid efflux of the free drug molecules from the MCTS, resulting in reduced concentration in the MCTS

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