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It is required for the production of myelin, the protective sheath that surrounds nerves and allows electrical signals to travel efficiently

However, the body metabolizes only part of the B12 pill, and thats after it goes through the digestive system first

The reported adverse reactions following parenteral administration of vitamin B12 include: Generalized: Anaphylaxis and death Cardiovascular: Pulmonary edema and congestive cardiac/heart failure during early treatment

Considering that the solitary use of either metformin, PPIs, or H 2 RAs, has been shown to considerably deplete vitamin B 12 , co-prescription of metformin with either PPIs or H2RAs can have additional adverse effects on vitamin B 12 status [92]