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Randomized trials show mixed results in terms of risk for adverse effects and great variability in the dosage used in trials may be partly to blame

It is noteworthy that this trial was conducted during the COVID-19 pandemic and reported an unusually high placebo response rate, probably amplified by behavioral, dietary, and psychosocial changes (110, 124)

11 Thats especially relevant for women, since both estrogen and growth hormone decline with age, causing skin to become thinner and less elastic over time

Results of a Phase II Study of Crenolanib in Relapsed/Refractory Acute Myeloid Leukemia Patients (Pts) with Activating FLT3 Mutations