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Yang GX, Peng DL, Chen L, Qian Y, He L, Chen XY, et al

Vedolizumab is more specific to the GI tract than other leucocyte adhesion inhibitors, such as natalizumab, and has been shown to be both safe and effective in IBD[8690]

This enzymatic degradation is entirely dependent on the methylation cycle, which relies on methylcobalamin to produce the universal methyl donor, SAMe