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NRF2 is inactivated by Kelch-like ECH-associated protein (KEAP)1, a protein that binds it and acts as a substrate adaptor for the Cullin-3-containing E3 (CUL3-RBX1) ubiquitin ligase, which ubiquitinizes NRF2 and promotes its degradation in the proteasome 45

Methods A completely randomized implementation design was used for the pot experiment: Soil Cd addition: add the soil in the form of CdCl 2 , mix it well and pile it up for one month to achieve the effect of stable form and uniform concentration

Acta 349 , 4552 (2004)

The medical application of quercetin is constrained by its poor water solubility, high metabolic rate, low oral bioavailability, and rapid clearance from the body (Sah et al., 2023