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On the other hand, a more recent study from 2015 found that beta-arbutin is more effective both on mouse melanoma cells and on human melanoma cells (btw, kojic acid was the most effective on human melanoma cells)

Notably, these effective concentrations were 16,000-80,000,000 times lower than concentrations of melatonin required for comparable effects, suggesting highly potent regulatory mechanisms rather than simple antioxidant activity