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The distance of L-lactate oxidation from the glycolytic enzymes and its proximity to these shuttles means that L-lactate formation facilitated the net restoration of cytosolic NAD+ and the achievement of net alkaline glycolysis

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10.1016/j.jaci.2023.10.002 4

Section 1899(i)(3) of the Act authorizes the Secretary to use other payment models, if the Secretary determines it is appropriate, and if the Secretary determines that doing so would improve the quality and efficiency of items and services furnished under Title XVIII and the alternative methodology would result in program expenditures equal to or lower than those that would result under the statutory payment model