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Neurophysiology 86, 16521660

Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis

Targeting ferritin via ferritinophagy inducers (e.g., NCOA4 modulation, MMRi compounds, high-dose vitamin C) can elevate labile iron, generate ROS, and sensitize brain cancer cellsparticularly CSCsto ferroptosis or other iron-dependent cell death pathways