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Professor Giovanna Traina from the University of Perugia explained via email to GMFH editors that a healthy intestinal barrier is essential for the maintenance of gastrointestinal health, but also for the systemic health of the host, as it is able to preserve the potential translocation of bacteria, food allergens, xenobiotics and inflammatory mediators in the systemic circulation, that may compromise the functionality of other organs. Such a defect in the gut barrier may facilitate dietary and microbial antigen influx, leading to the chronic inflammation involved in the onset of modern diseases

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Check local coverage determinations (LCDs) Review payer-specific guidelines Understand bundling rules with preventive services Always link an appropriate diagnosis code, and if applicable, report the drug separately using its respective J code

Chemical exfoliants provide immediate improvement in skin texture but dont directly stimulate collagen synthesis