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Handee W, Li X, Hall KW, Deng X, Li P, Benning C, Williams BL, Kuo MH

Study Credentials This report summarises PCR Corp independent clinical study ABUSUP1M, conducted at PCR Corp Manchester between December 2023 and March 2024

It has been demonstrated that the cAMP response element regulator (CREM) could induce the ICER isoform to promote Th17-cell differentiation, which also enhanced the expression of GLS1, the first enzyme in the Gln catabolic pathway, so that inhibition of GLS1 could improve Th17 differentiation in vitro and in mouse EAE (47)