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People with low B12 may experience: Persistent fatigue or low energy Weakness Brain fog, concentration issues, or memory changes Low mood or irritability Pins and needles, numbness, or nerve-type sensations Mouth ulcers or a sore tongue Paleness or shortness of breath (if anaemia is present) Some symptoms can become more serious if deficiency is prolonged, particularly neurological symptoms

(1) Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W

"Mitochondrial DNA mutations in disease and aging." Environmental and Molecular Mutagenesis, 2010

Brain-gut Axis and pentadecapeptide BPC 157: theoretical and practical implications