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To investigate the ability to generate a therapeutic effect, the multicellular tumor spheroids were treated with Ru(II)-OH, NP2, or NP4 (10 M Ru) in a 1% or 21% O 2 atmosphere and afterward incubated with a cell live or death stain

Studies have demonstrated that HIF-1 can reduce DNA damage in cancer cells through an unknown mechanism, further contributing to the drug resistance of several cancer types, including triple-negative breast cancer (TNBC) and prostate cancer (PC) (172)