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JAMA 218:10151022

S., Rathee P., Mulamukkil K., Ayoub Y., Komlosh A., et al

Bicarbonate Maintains Your Bloods pH Balance Bicarbonate is your bodys main acid-base buffer, keeping blood pH in the narrow range of 7.35 to 7.45

Anthracyclines Anthracycline drug family discovery is dated in the 1950s with daunorubicin isolation from Streptomyces peucetius ( Anthracycline anti-tumor effect depends on several mechanisms such as apoptosis induction via inhibition of topoisomerase II (TOP2), intercalation into the deoxyribonucleic acid (DNA) leading to an inhibition of macromolecules synthesis, or production of reactive oxygen species (ROS) causing DNA damage or lipid peroxidation ( Anti-tumor effect of anthracyclines is accompanied by dose-dependent cardiac toxicity that has been thoroughly investigated in studies trying to establish a safe dose of anthracyclines ( Cardiotoxicity of DOX clinically presents as both acute and chronic