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While direct experimental evidence comparing the responsiveness of specific -cell subpopulations to SCFAs, GLP-1, or other microbiota-derived metabolites remains limited, existing resources such as HPAP (Kaestner et al., 2019), reveal clear associations between -cell maturity, chromatin accessibility, metabolic state, and the capacity to sense exogenous signals

An outward-facing aromatic amino acid is crucial for signaling between the membrane-spanning and nucleotide-binding domains of multidrug resistance protein 1 (MRP1

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Positions in the sequence with high attention give more weight to the final prediction of the model