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The efficacy of the checkpoint inhibitor immunotherapy is augmented in the presence of Bifidobacterium and Bacillus fragilis through the shaping of the host immune system (145, 146)

Sometimes called cobalamin, B12 plays a significant role in neurological function and energy production

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In contrast, MYC was more activated in HCC tumors showing no benefit of the treatment, suggesting that MYC may trigger resistance of HCC cells to sorafenib