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These substances can be also produced by basophils, eosinophils, and macrophages under the influence of cytokines secreted by Th2 (IL-3, IL-4, IL-5, IL-13, GM-CSF) (182, 183)

Concurrently, GSH reduces Fe 3 + to Fe 2 + , which activates S 2 O 8 2 to generate highly toxic sulfate (SO 4 ) and hydroxyl radicals, inducing coordinated ferroptosis and pyroptosis in lung cancer cells 219